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"Neonatal and Pediatric Pharmacology offers guidelines for safe, effective, and rational drug therapy in newborns, children and adolescents. The book provides relevant and useful data on the molecular, physiologic, biochemical, and pharmacologic mechanisms of drug action and therapy in this population. The authors identify areas of innovative basic and translational research necessary for the continuing evaluation and development of drugs for the fetus, newborns, children and adolescents. Neonatal and Pediatric Pharmacology is is a valuable reference for all health care professionals who treat the fetus, newborns, children, and adolescents, including neonatologists, nurses, pediatricians, general practitioners, students, obstetricians, perinatologists, surgeons and allied health professionals. It will be useful anytime during the day and especially in the middle of the night when knowledge of appropriate indications, safe and effective use, dosage, and therapeutic regimen for a certain drug or molecular entity is immediately needed. The book is also directed to those involved in basic, clinical, and other academic pharmacological research, the pharmaceutical industry, and regulatory agencies dealing with drug and therapeutic developments for this population. Those teaching pharmacology and therapeutics will find this compilation of information extremely useful in preparing teaching materials"--Provided by publisher.… (more)
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CONTENTS:
Introduction and historical perspectives / Sumner J. Yaffe and Jacob V. Aranda
Clinical pharmacokinetics in infants and children / Edmund V. Capparelli
Drug action and therapy in the infant and child / Ralph E. Kauffman
Drug metabolism and disposition in infants and children / Anders Rane
Pharmacogenetics, pharmacogenomics, and pharmacoproteomics / J. Steven Leeder
Adherence with pediatric medication regimens / Hakan Ergun, Daniel A.C. Frattarelli, Doreen Matsui
Clinical trials involving children / Steven Herschfeld
Ethics of drug research in pediatric populations / Bruce A. Russell, Sanford N. Cohen, and Virginia Delaney Black
Therapeutic drug monitoring / Alexander A. Vinks and Philip D. Walson
Drug formulations / Milap C. Nahata
Developmental toxicology.
Sulfonamides / Chokechai Rongkavilit, Nahed Abdel-Haq, Jocelyn Y. Ang, and Basim I. Asmar
Penicillins, cephalosporins, and other ß-lactams / Sumathi Nambiar and William J. Rodriguez
Aminoglycosides and glycopeptides / Matthijs de Hoog and John N. van den Anker
Fluoroquinolones / Urs B. Schaad
Macrolides, Chloramphenicol, and Tetracyclines / Basim I. Asmar and Nahed M. Abdel-Haq
Anthelminthic drugs in children / David J. Diemert
Antituberculosis drugs / Alexander O. Tuazon and Cecilia C. Maramba-Lazarte
Antifungal agents / Michael Cohen-Wolkowiez, William J. Steinback, and Daniel K. Benjamin Jr.
Antiviral drugs: treatment of the fetus and newborn / Richard J. Whitley, Edward P. Acosta, and David W. Kimberlin
Anticonvulsants / Victoria Tutag Lehr, Merene Marhew, Harry T. Chungani, and Jacob V. Aranda
Psychopharmacology in children and adolescents / Adelaide Robb
Antihistamine drugs / Yesim Yilmaz-Demirdag, Sanaa A. Mahmoud, and Sami L. Bahna
Antiasthmatics / Hengameh H. Raissy, H. William Kelly, and Stanley J. Szefler
Antipyretics / John T. Wilson, Victoria Tutag Lehr, Erika Crane, and Margaret Ann Springer
Cardiovascular drugs / Eli Zalzstein and Rafael Gorodischer
Diuretics / Jean-Pierre Guignard
Clinical pharmacology of antineoplastic drugs / Stacey L. Berg, Lisa R. Bomgaars, and David G. Poplack.
Use of herbal products in children: risks and unproven benefits / Wayne R. Snodgrass and Susan C. Smolinske
Pharmacologic management of neonatal abstinence syndrome / Don T. Granger and Henrietta S. Bada
Drug interactions in newborns and children / Kelly P. Shaw and Shannon Manzi
Drug formulary for the newborn / Mirjana Lulic-Botica and J.V. Aranda
Pediatric drug formulary / Shannon F. Manzi, Alana Arnold, and Al Patterson.
General principles
Drugs and the newborn
Drugs in special populations and settings
Specific drugs
Adverse drug effects and interactions.