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This electronic version has been made available under a Creative Commons (BY-NC-ND) open access license. What does it mean to personalise cancer medicine? Drawing on an ethnographic study with cancer patients, carers and practitioners in the UK, this book traces their efforts to access and interpret novel genomic tests, information and treatments as they craft personal and collective futures. Exploring multiple experiences of new diagnostic tests, research programmes and trials, advocacy and experimental therapies, the authors chart the different kinds of care and work involved in efforts to personalise cancer medicine, as well as the ways in which benefits and opportunities are unevenly realised and distributed.Comparing these experiences with policy and professional accounts of the 'big' future of personalised healthcare, the authors show how hope and care are multi-faceted, contingent and, at times, frustrated in the everyday complexities of living and working with cancer.This book is available as an open access ebook under a CC-BY-NC-ND licence.… (more)
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https://www.ncbi.nlm.nih.gov/books/NBK567274/
CONTENTS:
Introduction: Exploring personalized cancer medicine
Future-crafting: great expectations and questions of value
1. Personalizing cancer treatment and diagnosis through genomic medicine
Targeted treatments: a start to the story of personalized genomic medicine for cancer
Targeted therapies proliferate
Personalizing prognosis, prediction and diagnosis
Adaptive trials
Whole genome sequencing
2. Genomic techniques in standard care: gene-expression profiling in early-stage breast cancer
Gene-expression profiling within the UK NHS: crafting genomic futures
Integrating genomic tumor profiling in practice
Treatment decision making for early-stage breast cancer: patient accounts of Oncotype DX
3. Molecular profiling for advanced gynecological cancer: prolonging foreshortened futures
Precision oncology for advanced gynecological cancers
Virtue’s VGT: case study
Patient accounts of participation in the VGT study
4. Optimizing personalization: adaptive trials for intractable cancers
Stratified medicine and an adaptive trial
Making the trial work
Patients accessing and being on trial
5. Genomics at scale: participation to build the bioeconomy
Genomics and the health of the nation
Transformations in cancer care: participation for practitioners
Patient participation
6. Going private: digital culture and personalized medicine
Private healthcare as right and wrong: personal futures and the future of the NHS
Crowdfunding: crafting futures in the digital economy
7. At the limits of participation
Scoping personalized cancer medicine
Accessing personalized medicine participants
Public engagement
Conclusion: Future-crafting
Crafting futures as care work in personalized cancer medicine
Crafting futures together
Recrafting value
Conclusion: revaluing research and care